According to AV-Comparatives MSE has better detection rate. According to PCMag, Panda Cloud isn't good at removing malware (but it has good detection - still not better than MSE). MSE also uses a cloud-based service that compares file behaviour across computers to discover 0-day malware. MSE works when you are offline, while Panda Cloud needs Internet connection. Both are easy to use and come pre-configured. On the other hand, Panda Cloud is lighter on system resources.
You can try them both for a period of time (not at the same time, of course) and decide for yourself.